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Pravachol

Pravachol (Pravastatin) is an HMG-CoA reductase inhibitor, also known as a statin. It works by reducing the production of certain fatty substances in the body, including cholesterol. Generic Pravachol is the most studied cholesterol-lowering drug in clinical trials.

Generic Pravachol may also be marketed as: Pravastatin, Pravachol, Selektine.

*Pravachol® is manufactured by by Bristol-Myers Squibb.

Uses

Pravastatin is used for lowering high cholesterol and triglycerides in certain patients. It also increases high-density lipoprotein (HDL, good) cholesterol levels. It is used along with an appropriate diet. It is also used in certain patients to reduce the risk of heart attack, stroke, and death due to coronary heart disease. It is also used to slow blood vessel blockage and to reduce the need for medical procedures to open blocked blood vessels.

How to take

Take Generic Pravachol by mouth with or without food. Continue to take Generic Pravachol even if you feel well. Do not miss any doses.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Generic Pravachol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking Generic Pravachol and call your doctor at once if you have any of these serious side effects:

  • unexplained muscle pain, tenderness, or weakness;
  • confusion, memory problems;
  • fever, unusual tiredness, and dark colored urine;
  • chest pain;
  • increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);
  • swelling, weight gain, urinating less than usual or not at all; or
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious Generic Pravachol side effects may include:

  • headache;
  • mild muscle pain;
  • diarrhea;
  • mild skin rash; or
  • dizziness.

This is not a complete list of side effects and others may occur.

Precautions

If you also take cholestyramine (Prevalite, Questran) or colestipol (Colestid), avoid taking them within 1 hour after or 4 hours before you take Pravachol.

Avoid eating foods that are high in fat or cholesterol. Pravachol will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

Grapefruit and grapefruit juice may interact with Pravachol. Discuss the use of grapefruit products with your doctor.

Drug interactions

Before taking Generic Pravachol, tell your doctor about all other medicines you are using, especially:

  • cimetidine (Tagamet);
  • spironolactone (Aldactone, Aldactazide); or
  • any other "statin" medication such as atorvastatin (Lipitor, Caduet), fluvastatin (Lescol), lovastatin (Altoprev, Mevacor), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor, Vytorin).

This list is not complete and other drugs may interact with Generic Pravachol.

Missed dose

If you miss a dose of Generic Pravachol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take two doses at once.

Storage

Store Generic Pravachol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pravastatin out of the reach of children and away from pets.