Glucophage (Metformin) is used to treat a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. With this type of diabetes, insulin produced by the pancreas is not able to get sugar into the cells of the body where it can work properly. Generic Glucophage is the first-line drug of choice for type 2 diabetes.

Glucophage may also be marketed as: Diabex, Diaformin, Fortamet, Metformin, Riomet.

*Glucophage® is manufactured by Bristol-Myers Squibb.


Generic Glucophage (metformin) is an oral diabetes medicine that helps control blood sugar levels. Generic Glucophage is for people with type 2 diabetes. Glucophage is sometimes used in combination with insulin or other medications, but it is not for treating type 1 diabetes.

How to take

Take Generic Glucophage exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Take Generic Glucophage with a meal, unless your doctor tells you otherwise. Generic Glucophage XR should generally be taken once daily with the evening meal. Follow your doctor's instructions.

Side effects


Get emergency medical help if you have any of these signs of an allergic reaction to Glucophage: hives; difficult breathing; swelling of your face, lips, tongue, or throat. This medication may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time.

Get emergency medical help if you have even mild symptoms of lactic acidosis, such as:

  • muscle pain or weakness;
  • numb or cold feeling in your arms and legs;
  • trouble breathing;
  • feeling dizzy, light-headed, tired, or very weak;
  • stomach pain, nausea with vomiting; or
  • slow or uneven heart rate.
  • Call your doctor at once if you have any other serious side effect such as:
  • feeling short of breath, even with mild exertion;
  • swelling or rapid weight gain; or
  • fever, chills, body aches, flu symptoms.

Less serious Generic Glucophage side effects may include:

  • headache or muscle pain;
  • weakness; or
  • mild nausea, vomiting, diarrhea, gas, stomach pain.

This is not a complete list of side effects and others may occur.


Do not skip meals. If you are exercising much more than usual you may need extra snacks to avoid side effects caused by low blood sugar.

Do not change your medication dose without talking to your prescriber. If you have mild symptoms of low blood sugar, eat or drink something containing sugar at once and contact your health care professional.

Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis while taking Generic Glucophage.

Drug interactions


Tell your doctor about all other medicines you use, especially:

  • furosemide (Lasix);
  • nifedipine (Adalat, Procardia);
  • cimetidine (Tagamet) or ranitidine (Zantac);
  • amiloride (Midamor) or triamterene (Dyrenium);
  • digoxin (Lanoxin);
  • morphine (MS Contin, Kadian, Oramorph);
  • procainamide (Procan, Pronestyl, Procanbid);
  • quinidine (Quin-G) or quinine (Qualaquin);
  • trimethoprim (Proloprim, Primsol, Bactrim, Cotrim, Septra); or
  • vancomycin (Vancocin, Lyphocin).


Missed dose
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture and light. Keep out of the reach of children in a container that small children cannot open. Throw away any unused medicine after the expiration date.