Dapsone (diamino-diphenyl sulfone) is an anti-infective medication. It is one of the leading medications and continues to be a powerful therapeutic tool in many skin diseases. The active ingredient in leading antibiotic drugs such as Aczone, Dapsone has been the principal drug in a multidrug therapy (MDT) recommended by the World Health Organization for the treatment of leprosy!
Dapsone is also marketed as: Aczone.
Dapsone is mainly used to treat leprosy. It is also used to treat dermatitis herpetiformis (extremely itchy groups of skin lesions, usually occurring on the elbows, knees, and scalp). In addition, it is used for second-line treatment for prophylaxis (prevention) against Pneumocystis pneumonia.
As an antibacterial, Dapsone inhibits bacterial synthesis of dihydrofolic acid, via competition with para-aminobenzoate for the active site of dihydropteroate synthetase.
Take Dapsone exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass of water.
Taking Dapsone with food may decrease stomach upset, should it occur.
It is important to take Dapsone regularly to get the most benefit.
Your doctor may want you to have blood tests or other forms of monitoring during treatment with Dapsone.
In rare cases, Dapsone has been associated with serious, and sometimes fatal blood and/or liver problems. Contact your doctor immediately if you experience a sore throat, fever, pale skin, bruising or pinpoint red spots on the skin, or yellowing of the skin or eyes. These may be symptoms of blood or liver problems.
Contact your doctor immediately if you develop a rash while taking Dapsone. In rare cases, Dapsone has been associated with serious, and sometimes fatal, skin reactions.
If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:
an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
Side effects other than those listed here may also occur.
Avoid prolonged exposure to sunlight. Dapsone may increase the sensitivity of the skin to sunlight and sunburn may be more likely to occur. If exposure to the sun is unavoidable, wear a sunscreen and protective clothing.
Do not take Dapsone without first talking to your doctor if you have:
You may not be able to take Dapsone, or you may require a dosage adjustment or special monitoring if you have any of the conditions listed above.
Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose of this medication, unless otherwise directed by your doctor.
Store Dapsone at room temperature away from moisture and heat.