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Cilostazol

Cilostazol is used to treat the symptoms of intermittent claudication. Cilostazol is the active ingredient in the popular medication Pletal, manufactured by Teva Pharmaceuticals. It can relieve many painful symptoms and increase the distance you are able to walk. Order it today and experience better health!

Cilostazol is also marketed as: Pletal

Uses

Cilostazol is a medication for the treatment of intermittent claudication, a condition caused by narrowing of the arteries that supply the legs with blood. Patients with intermittent claudication develop pain when they walk because not enough oxygen-containing blood reaches the active leg muscles.

Cilostazol reduces the pain of intermittent claudication by dilating the arteries, thereby improving the flow of blood and oxygen to the legs. (It does this by decreasing the action of an enzyme, phosphodiesterase III.) It also reduces the ability of blood to clot. Cilostazol enables patients with intermittent claudication to walk longer and faster before developing pain.

How to take

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

Take each dose with a full glass of water.

Cilostazol is usually taken twice a day, at least 30 minutes before or 2 hours after breakfast or dinner. Take Cilostazol at the same times each day. Follow your doctor's instructions.

It may take up to 12 weeks of using Cilostazol before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 4 weeks of treatment.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe headache;
  • bloody urine, painful urination;
  • fever, chills, body aches, flu symptoms;
  • chest pain;
  • feeling short of breath, even with mild exertion; or
  • swelling of your ankles or feet.
  • Less serious side effects may include:
  • fast or pounding heartbeats;
  • diarrhea, vomiting;
  • weakness, dizziness;
  • leg cramps;
  • numbness or tingling;
  • joint pain; or
  • cough, runny or stuffy nose.

This is not a complete list of side effects and others may occur.

Precautions

Do not take Cilostazol if you have congestive heart failure. Cilostazol can make this condition worse.

It may take up to 12 weeks of using Cilostazol before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 4 weeks of treatment.

Grapefruit and grapefruit juice may interact with Cilostazol. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Drug interactions

Before taking Cilostazol, tell your doctor if you are using any of the following drugs:

  • clopidogrel (Plavix);
  • omeprazole (Prilosec, Zegerid) or esomeprazole (Nexium);
  • erythromycin (E.E.S., Ery-Tab, E-Mycin, Erythrocin) or clarithromycin (Biaxin);
  • ketoconazole (Nizoral), fluconazole (Diflucan), or itraconazole (Sporanox);
  • diltiazem (Cardizem, Tiazac); or
  • fluvoxamine (Luvox), fluoxetine (Prozac), sertraline (Zoloft), or nefazodone (Serzone).

This list is not complete and there may be other drugs that can interact with Cilostazol.

Missed dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Storage

Store Cilostazol at room temperature away from moisture, heat, and light.