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Benemid

Generic Benemid (Probenecid) helps your body pass uric acid out through the urine, which lowers the levels of uric acid in the body. Generic Benemid is one of Merck & Company Inc. best-selling drugs and is mainly prescribed for preventing gout and gouty arthritis.

Generic Benemid is also marketed as Probenecid.

*Benemid® is manufactured by Merck & Company Inc.

Uses

This medication is used to prevent gout and gouty arthritis. It will not treat a sudden/severe attack of gout. Generic Benemid belongs to a class of drugs known as uricosurics. It lowers high levels of uric acid in your body by helping the kidneys to get rid of uric acid. When uric acid levels get too high, crystals can form in the joints, causing gout. Lowering uric acid levels may also help your kidneys.

Probenecid is sometimes used along with penicillin antibiotics to increase antibiotic blood levels. This increase makes the antibiotic work better at treating certain infections.

How to take

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Drink plenty of water to prevent kidney stones while you are taking Generic Benemid.

Generic Benemid may be only part of a complete program of treatment that also includes diet, other medications, and mineral supplements. Follow your doctor's instructions.

To be sure this medication is not causing harmful effects, your blood or urine may need to be tested on a regular basis. Do not miss any scheduled appointments.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Generic Benemid. This medication may affect your body's response to anesthesia.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • worsening gout symptoms;
  • severe pain in your side or lower back;
  • blood in your urine;
  • swelling, especially in your face, stomach, ankles, or feet; or
  • pale or yellowed skin, dark colored urine, fever, confusion or weakness.

Less serious side effects may include:

  • urinating more than usual;
  • mild nausea, vomiting, loss of appetite;
  • headache, dizziness;
  • sore gums;
  • mild itching or skin rash;
  • hair loss; or
  • warmth, redness, or tingly feeling under your skin.

This is not a complete list of side effects and others may occur.

Precautions

You should not use this medication if you are allergic to Generic Benemid, or if you have uric acid kidney stones, a gout attack that has already started, or a blood cell disorder such as anemia, or decreased white blood cells.

Drink plenty of water to prevent kidney stones while you are taking Generic Benemid.

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using Generic Benemid.

Drug interactions

Always read the ingredients before taking this or any other medication to ensure that there are no elements that may elicit an allergic reaction. Many drugs can interact with Generic Benemid. Below is just a partial list. Tell your doctor if you are using:

  • lorazepam (Ativan);
  • methotrexate (Rheumatrex, Trexall);
  • rifampin (Rifadin, Rifamate, Rimactane);
  • diabetes medication you take by mouth;
  • an NSAID (nonsteroidal anti-inflammatory drug) such as ketoprofen (Orudis, Oruvail), indomethacin (Indocin), meclofenamate (Meclomen), or naproxen (Aleve, Anaprox, Naprosyn);
  • salicylates such as aspirin, Novasal, Doan's Extra Strength, Salflex, Tricosal, and others; or
  • a sulfa drug such as Bactrim, Cotrim, Septra, SMX/TMP, and others.

This list is not complete and there may be other drugs that can interact with Generic Benemid.

Missed dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

Storage

Store Generic Benemid at room temperature away from moisture and heat.